What ketamine treatment looks like in South Florida
If you live in South Florida and are researching ketamine, you'll encounter a range of clinics, medications, and delivery models. This guide is written to help you compare them fairly — not to steer you toward any single option. Whatever you choose, ketamine is a medical treatment, and candidacy should be determined only after a clinical evaluation by a licensed provider.
Two points frame everything below. First, intravenous ketamine for mental health is off-label — ketamine itself is FDA-approved only as an anesthetic. Second, the only ketamine-related medication FDA-approved for psychiatric use is intranasal esketamine (Spravato), for specific depression indications. Results vary from person to person, and no responsible provider can guarantee an outcome.
The two most common paths
IV ketamine (off-label)
IV ketamine delivers a precisely measured, low dose into the bloodstream over a controlled infusion in a medical office, with monitoring throughout. Its use for depression, anxiety, and PTSD is off-label, meaning it is prescribed at a provider's clinical discretion based on a growing body of research rather than a specific FDA approval for those conditions.
Spravato / esketamine (FDA-approved)
Spravato (esketamine) is FDA-approved for treatment-resistant depression — where current labeling permits it as monotherapy or together with an oral antidepressant — and for depressive symptoms in adults with major depressive disorder with acute suicidal ideation or behavior, where it is used together with an oral antidepressant. By its labeling it can only be dispensed and administered in REMS-certified centers, where you take the nasal spray under supervision and are observed in-office for a period afterward before going home.
Other administration models people encounter
Beyond IV and Spravato, several delivery models exist. Here they are described factually, with the monitoring tradeoffs — not as an endorsement or a criticism of any provider who offers them.
Intravenous (IV) ketamine
Delivered into a vein over a controlled infusion in a medical office, IV allows precise, adjustable dosing with continuous monitoring of vital signs. This use for mental health is off-label. Its tradeoff is that it requires an in-office visit and clinical oversight.
Intramuscular (IM) ketamine
Given as an injection into a muscle, IM is also administered in-office and off-label for psychiatric use. Dosing cannot be paused or titrated once given the way an infusion can, so some providers weigh that against its simplicity.
Oral / sublingual troches
Compounded lozenges or troches are taken by mouth and are off-label. Absorption is more variable than IV or IM, and some at-home programs use them. The monitoring tradeoff is that effects are less predictable and observation may be limited compared with an office setting.
Intranasal esketamine (Spravato)
Spravato is FDA-approved for specific depression indications and, by its labeling, must be given in a REMS-certified healthcare setting with a period of in-office observation afterward. This monitoring is a requirement of the approval, not an optional add-on.
At-home telehealth models
Some companies prescribe sublingual ketamine for use at home following a video evaluation. People encounter these models across Florida; the main monitoring tradeoff is the absence of in-person clinical observation during the experience, which some clinicians consider a meaningful safety difference.
Every model above should follow a clinical evaluation. The right choice depends on your diagnosis, history, and preferences — something to discuss with a licensed provider.
General insurance considerations
Coverage varies and changes, so treat the following as general orientation rather than a promise about your specific plan. IV ketamine for mental health is typically self-pay, because its psychiatric use is off-label; some patients ask about HSA/FSA funds or partial reimbursement, with results that differ by plan.
Because Spravato is FDA-approved, it more often has an insurance pathway than IV ketamine, though prior authorization, deductibles, and site requirements still apply and outcomes vary. Any clinic you consider should be able to explain, in writing, what is and isn't included in its pricing so you can compare fairly.
Questions about treatment setting and monitoring
Where and how you're monitored is one of the clearest ways delivery models differ. Ask any provider who is present during treatment, what vital signs are monitored, how long you're observed afterward, and what happens if something feels wrong. In-office models such as IV, IM, and Spravato include real-time observation; at-home models generally do not, which is a tradeoff worth understanding before you decide.
There is no single "correct" setting for everyone — but the monitoring plan should be explicit, not vague, and it should match the medication and dose being used.
Transportation and treatment-day planning
After IV, IM, or intranasal ketamine you should not drive for the rest of the day. Plan a ride home in advance — a friend, family member, or rideshare — and keep the remainder of your day light and low-key. In the Miami-Dade, Broward, and Palm Beach area this can also mean accounting for traffic and travel time to and from the clinic.
A responsible clinic raises ride-home planning up front rather than as an afterthought, and will tell you roughly how long to budget for observation and recovery before you leave.
How to evaluate a provider
The most useful thing you can do is ask the same questions of every clinic you're considering. A separate patient guide walks through the screening, monitoring, FDA-status, dosing, and pricing questions worth asking — along with the red-flag answers that should give you pause.
About Infinity Medical Wellness
For transparency: Infinity Medical Wellness provides IV ketamine (off-label for psychiatric use) at a single office in Brickell, Miami, serving patients from across South Florida. We're one of several options in the region — this guide is meant to help you compare all of them on their merits. If you'd like to talk through whether IV ketamine may be reasonable for you, a consultation is the place to start.
Frequently Asked Questions
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Medical disclaimer. This page is for educational purposes only and does not provide medical advice, diagnosis, or treatment. Ketamine is used off-label for mental health conditions, is not appropriate for everyone, and individual results vary. Candidacy is determined only after a clinical evaluation by a licensed medical provider. If you are in crisis or thinking about harming yourself, call or text 988 or go to the nearest emergency room.